Genetics

3. (4 pts). A diploid somatic cell of a hypothetical eukaryote contains two pairs of homologs in its nucleus (2N = 4).  One pair of homologs is metacentric and the other pair is telocentric.  The metacentric pair is heterozygous at two gene loci and each locus is on a different arm.  At one locus, the alleles are identified by the letters “A” and “a”.  At the other locus, the alleles are identified by the letters “B” and “b”.  The upper case letter indicates the dominant allele and the lower case indicates the recessive allele at each locus.  The dominant alleles of the two gene loci are on one of the metacentric homologs and the recessive alleles are on the other metacentric homolog.  The telocentric homologs are heterozygous for two loci on the long arm.  The locus closest to the centromere has alleles symbolized by the letters “E” and “e” while the other locus on the telocentric homologs has alleles represented by the letters “H” and “h” .  The dominant alleles of those 2 loci are on one of the telocentric chromosomes while the recessive alleles are on the other homolog.

For the stage of the cell cycle listed below, please draw and label the chromosomes as instructed below and using the allele symbols. Use a vertical line to represent each double-stranded DNA molecule and an open circle,   , to indicate the site of the centromere.  Clearly label the positions of the centromeres, telomeres, each gene locus and the allele at each gene locus on each chromosome and chromatid.  Please do not draw other structures such as the nuclear envelope, spindle fibers etc.   Pretend that the chromosomes are sufficiently condensed so that they could be observed as distinct chromosomes. The stage of the cell cycle is:  telophase of mitosis (draw the chromosomes that you would expect in one nucleus).  Neatly illustrate and label your chromosomes in the box:

For the stage of the cell cycle listed below, please draw and label the chromosomes as instructed below and using the allele symbols. Use a vertical line to represent each double-stranded DNA molecule and an open circle, to indicate the site of the centromere.  Clearly label the positions of the centromeres, telomeres, each gene locus and the allele at each gene locus on each chromosome and chromatid.  Please do not draw other structures such as the nuclear envelope, spindle fibers etc.   Pretend that the chromosomes are sufficiently condensed so that they could be observed as distinct chromosomes. The stage of the cell cycle is:  telophase of mitosis (draw the chromosomes that you would expect in one nucleus).  Neatly illustrate and label your chromosomes in the box:

For the stage of the cell cycle listed below, please draw and label the chromosomes as instructed below and using the allele symbols. Use a vertical line to represent each double-stranded DNA molecule and an open circle,   , to indicate the site of the centromere.  Clearly label the positions of the centromeres, telomeres, each gene locus and the allele at each gene locus on each chromosome and chromatid.  Please do not draw other structures such as the nuclear envelope, spindle fibers etc.   Pretend that the chromosomes are sufficiently condensed so that they could be observed as distinct chromosomes. The stage of the cell cycle is:  telophase of mitosis (draw the chromosomes that you would expect in one nucleus).  Neatly illustrate and label your chromosomes in the box:

5. (2 pts). The probability of a specific combination of offspring =   { n! / (w! x!)} multiplied by pw multiplied by   q x. Where n, w and x refer to numbers of observations (e.g. progeny) and p and q refer to the probability of the respective observation. A man and a woman are heterozygous for cystic fibrosis, an autosomal recessive disorder: ie., both are carriers (genotype Aa).

_______: (2 pts) what is the probability that, if they have 5 children by separate conceptions and births, 1 will have CF and 4 will be normal? Show your work.

7. Two pea plants, each with genotype SsYyDd, are mated with each other.  Gene loci S and Y are as described in the text and lecture notes.  The third locus affects plant stature, allele D for tall and allele d for short.  The 3 loci segregate independently of each other.

______: the expected frequency of gametes carrying alleles SyD.

______: the expected frequency of progeny with genotype SsYYdd.

______: the expected frequency of progeny with phenotype smooth, green and tall.

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