Translation of science into medicine

Cellular prion protein (PrPc) is a high affinity receptor for soluble oligomeric AB42 (see Figure 2, Strittmater et al., 2010), mediating toxic effects on synaptic plasticity. PrPc represents a target in Alzheimer?s disease (AD) directly disrupting the signaling pathway of soluble A?42.

Please address the following questions.

1) Describe an in vivo experiment that would validate this target as a disease modifying therapy for AD using a specific monoclonal anti-PrPc antibody. In your answer justify and describe your chosen disease animal model of AD, treatment groups and chosen endpoints to measure disease modification. Discuss the validity of your chosen disease animal model.

2) Define the term pharmacodynamic (PD) marker. Describe why PD markers are essential to any drug development programme. Propose a possible PD marker for an anti-PrPc antibody.

To help you address the questions above refer to the attached publications Chung et al., 2010 and Strittmater et al., 2010, my lecture notes (TSM and TP), in vivo experimental design practical notes as well as additional reading. The pdf attachments are uploaded under my teaching folder.


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