Stastical genetics

Compare and contrast linkage and association methods of statistical genetics. Examine the differences in design, hypothesis being tested, genetic variants being

investigated, assumptions for testing being made, populations studied, statistical power, and indications for each method. Use “real world” examples from research

publications in your discussion.

Please provide discussion about alpha levels/or p values and debates about appropriate cut-offs
Recent literature regarding important debates about association and linkage studies should be included (e.g. missing heritability, approaches to use with sequence

data, what types of markers can be utilized in linkage versus association studies).

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