Biochemistry Bpharm-Sem-IV

Biochemistry Bpharm-Sem-IV

1.  Explain  Transamination  reaction  with  two  examples. What  is  the  significance  of
this reaction?

2.  How  is  ammonia  formed  in  the  body? Explain  the  reactions  leading  to  the
detoxification of ammonia in the brain and liver.

3.  Define  buffers?  Name  the  blood  buffers?  Write  the  Henderson-Hasselbach
equation?

4.  List  the  Acid  base  disorders  and  write  the  biochemical  findings  in  them  with
regard to pH, HCO3
-, PCO
2?

5.  Explain with help of diagram Respiratory and renal regulation of blood pH?

6.  List the important biological substances formed from glycine?

7.  Name the enzyme defect and signs and symptoms of  the following inborn errors
of metabolism:
I.  Phenylketonuria
II.  Alkaptonuria
III.  Maple syrup urine disease
IV.  Primary hyperoxaluria
V.  Glycinuria
VI.  Homocystinuria

8.  Define replication and list in points the process of replication?

9.  List in points the process of transcription?

10. Write the normal range of blood glucose levels in fasting and 2-hour postprandial.
Explain  the  hormonal  regulation  of  blood  glucose  level.  What  is  normal  renal
threshold for glucose? Enumerate the conditions in which glycosuria is found?

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