biochemistry

My essay is about tyrosine tested in PKU on the techniques as seen below the important aspect are the techniques and I need to know which one was used in the passed for screening and what is

used now at this stage and why like it to accuracy and the clinical analytical sensitivity and specificity screening for PKU is been around few year how this they improved in the techniques over

the years please base it only on these techniques: not to write about other then theses techniques thanks
• HPLC
• Spectrometry
• Liquid-Chromatography tandem Mass Spectrometry (LC–MS/MS)
Critical evaluation of the two methodologies HLPC AND SPECTROMETRY which one would be the better one to use for the analysis of tyrosine and why is it the best one?
[100 words]

What is other body fluid where tyrosine is tested from beside on the dried blood on paper and on which technique? What is it tested for? [50 words]

Critical evaluation of different analytes of the two methodologies HLPC AND SPECTROMETRY sensitivity and specificity comment on the type of body fluid it is and why is it better/ or no

difference compared with dried blood on paper? [100 words]

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