DNA replication

Select one of the enzymes involved in DNA replication or repair and find a disease related to a mutation in this enzyme
For example, Bloom Syndrome is caused by a mutation in one of the helicase enzymes involved in DNA replication. Select

one of the enzymes involved in DNA replication or repair and find a disease related to a mutation in this enzyme
at least 3 pages, address the following topics:

What is the specific mutation?
What are the symptoms of the disease?
How was the relationship between the mutation and the disease discovered?
How does this mutation impact DNA replication and repair and how is this different from normal DNA replication?
How does this mutation impact transcription and translation and how is this different from normal transcription and

translation?
How does this problem in DNA replication lead to one symptom of the disease?
Give two examples of how genetic engineering technology could be used to learn more about, detect earlier, or treat this

disease? Be sure to include a description of what genetic engineering is.

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