Biochemistry Bpharm-Sem-IV

1. Explain Transamination reaction with two examples. What is the significance of
this reaction?

2. How is ammonia formed in the body? Explain the reactions leading to the
detoxification of ammonia in the brain and liver.

3. Define buffers? Name the blood buffers? Write the Henderson-Hasselbach
equation?

4. List the Acid base disorders and write the biochemical findings in them with
regard to pH, HCO3
-, PCO
2?

5. Explain with help of diagram Respiratory and renal regulation of blood pH?

6. List the important biological substances formed from glycine?

7. Name the enzyme defect and signs and symptoms of the following inborn errors
of metabolism:
I. Phenylketonuria
II. Alkaptonuria
III. Maple syrup urine disease
IV. Primary hyperoxaluria
V. Glycinuria
VI. Homocystinuria

8. Define replication and list in points the process of replication?

9. List in points the process of transcription?

10. Write the normal range of blood glucose levels in fasting and 2-hour postprandial.
Explain the hormonal regulation of blood glucose level. What is normal renal
threshold for glucose? Enumerate the conditions in which glycosuria is found?

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