A) hemoglobin B) Sickle cell anemia

A) hemoglobin B) Sickle cell anemia
a)model (any material) of hemoglobin(hmg) with correct labeling and appropriate location of oxygen.submit picture of model.
b)text explanation of the differences between oxygenated and deoxygenated states of the hmg.
c) diagram or graph showing relationship between hmg’s affinity for oxygen:how much it binds and pH.
d)briefly explain the Bohr’s effect: mention where in the body you would see high/low pH and how that allows Hmg to do it’s job.
d) Diagram showing differences btwn myoglobin and hmg. clearly show how O2 binds to both proteins showing all necessary parts.
e)Two Diagrams: (1)show the ‘cellular level’ differences of normal red blood cells to the sicled red blood cells.(2) differences at ‘molecular level’ (amino acid level)
f)text explanation: comparing O2 carrying capacity for BOTH sickle cell and normal red blood cells. Attributes to consider here: shapes, flexiblilty,O2 deliverind efficiences, oxygenation cycles, lifespans, etc.
g)explanation/discussion: molecular (recessive or dominant?) inheritance pattern (genetic outcomes for children from two parents who are carriers of sickle cell gene with four possibilities in the offspring. discuss the ‘pattern’ of inheritence.
h)diagram: pedigree with two parents who are carriers: show which genes each child has inherited and expected %’s for each result and state the outcomes as normal, carrier or disease.
Please cite (in-text) and references all sources.
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