BIOCHEMISTRY

| January 24, 2016

Competency 208.5.3: Protein Function—Myoglobin and Hemoglobin – The graduate constructs models of various states of hemoglobin, demonstrates how changes in the usual configuration of hemoglobin can lead to molecular disease, and distinguishes between the chemical structure and function of hemoglobin and myoglobin.

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Task 3: Protein Function

Introduction:

Hemoglobin is an essential protein necessary for the transport of oxygen in the body. Biochemists study the molecular activities necessary for the exchange and transport of oxygen between the body cells and lungs.

You should compile your work for this task in a single document (e.g., Microsoft Word, Google Document) that includes diagrams, models, text explanations, and references. If a requirement asks for an explanation, you should provide a written response in a narrative style (i.e., complete sentences rather than bullet points).

Note: Multimedia presentations (e.g., PowerPoint, Keynote) will not be accepted due to potential originality concerns.

Note: Please save submission documents as *.doc, *.docx, *.rtf, or *.pdf files. If you are using Google Documents, you must save the file in *.pdf format and upload the *.pdf file.

Requirements:

A. Create an original model of hemoglobin, with clear labels, that shows how oxygen is carried by the molecule.

Note: The inclusion of the following components aids in showing how oxygen is carried: subunits, heme groups, iron atoms, and oxygen molecules.

Note: Take a picture or screenshot of your completed model as evidence that you created it. You can include the picture or screenshot as part of your document, or you can submit it in Taskstream as a separate attachment.

1. Explain two differences between the oxygenated and deoxygenated states of hemoglobin.

2. Explain how pH impacts the binding and release of oxygen by hemoglobin.

a. Create an original graph that demonstrates the relationship between hemoglobin’s oxygen binding and oxygen concentration at different pH levels.

3. Create an original diagram, or series of diagrams, with clear labels, that compares the biochemical (protein) structure of hemoglobin to myoglobin.

Note: The inclusion of the following components aids in showing the comparison: subunits, heme groups, and iron atoms.

Note: Take a picture or screenshot of your completed diagram as evidence that you created it. You can include the picture or screenshot as part of your document, or you can submit it in Taskstream as a separate attachment.

B. Demonstrate your understanding of sickle cell anemia by doing the following:

1. Create an original diagram that demonstrates the amino acid difference between normal and sickle forms of hemoglobin.

Note: Take a picture or screenshot of your completed diagram. You can include the picture or screenshot as part of your document, or you can submit it in Taskstream as a separate attachment.

2. Create an original diagram that demonstrates the difference between normal and sickle red blood cells at the cellular level.

Note: Take a picture or screenshot of your completed diagram. You can include the picture or screenshot as part of your document, or you can submit it in Taskstream as a separate attachment.

3. Explain how diseased cells differ from normal red blood cells in their capacity to transport oxygen.

4. Explain the molecular inheritance of sickle cell anemia by doing the following:

a. Identify the type of inheritance seen in sickle cell anemia.

b. Create an original diagram (e.g., pedigree charts, Punnett squares), or series of simple diagrams, that demonstrates how sickle cell genes are inherited.

Note: Take a picture or screenshot of your completed diagram. You can include the picture or screenshot as part of your document, or you can submit it in Taskstream as a separate attachment.

C. When you use sources, include all in-text citations and references in APA format.

Note: For definitions of terms commonly used in the rubric, see the attached Rubric Terms.

Note: When using sources to support ideas and elements in an assessment, the submission MUST include APA formatted in-text citations with a corresponding reference list for any direct quotes or paraphrasing. It is not necessary to list sources that were consulted if they have not been quoted or paraphrased in the text of the assessment.

Note: No more than a combined total of 30% of a submission can be directly quoted or closely paraphrased from sources, even if cited correctly. For tips on using APA style, please refer to the APA Handout web link included in the General Instructions section.

Evaluation Method

This part is Rubric check.

Note You may wish to change your printer settings to “landscape” mode if you have a rubric with many levels. Send to Printer Now

JBT Task 3 (0515)

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value: 0.00 value: 1.00 value: 2.00 Score/Level

Articulation of Response (clarity, organization, mechanics) The candidate provides unsatisfactory articulation of response. The candidate provides weak articulation of response. The candidate provides adequate articulation of response.

A. Model of Hemoglobin The candidate does not provide an original model of hemoglobin, with clear labels, that shows how oxygen is carried by the molecule. The candidate provides an inaccurate or incomplete original model of hemoglobin, with clear labels, that shows how oxygen is carried by the molecule. The candidate provides an accurate and complete original model of hemoglobin, with clear labels, that shows how oxygen is carried by the molecule.

A1. Oxygenated and Deoxygenated States of Hemoglobin The candidate does not provide a logical explanation of any differences between the oxygenated and deoxygenated states of hemoglobin. The candidate provides a logical explanation, with sufficient detail, of 1 difference between the oxygenated and deoxygenated states of hemoglobin. The candidate provides a logical explanation, with sufficient detail, of 2 differences between the oxygenated and deoxygenated states of hemoglobin.

A2. Impact of pH on Binding and Release of Oxygen The candidate does not provide a logical explanation of how pH impacts the binding and release of oxygen by hemoglobin. The candidate provides a logical explanation, with insufficient detail, of how pH impacts the binding and release of oxygen by hemoglobin. The candidate provides a logical explanation, with sufficient detail, of how pH impacts the binding and release of oxygen by hemoglobin.

A2a. Graph of Oxygen Binding and Concentration The candidate does not provide an original graph that demonstrates the relationship between hemoglobin’s oxygen binding and oxygen concentration at different pH levels. The candidate provides an inaccurate or incomplete original graph that demonstrates the relationship between hemoglobin’s oxygen binding and oxygen concentration at different pH levels. The candidate provides an accurate and complete original graph that demonstrates the relationship between hemoglobin’s oxygen binding and oxygen concentration at different pH levels.

A3. Diagram of Biochemical Structures The candidate does not provide an original diagram, or series of diagrams, with clear labels, that compares the biochemical structure of hemoglobin to myoglobin. The candidate provides an inaccurate or incomplete original diagram, or series of diagrams, with clear labels, that compares the biochemical structure of hemoglobin to myoglobin. The candidate provides an accurate and complete original diagram, or series of diagrams, with clear labels, that compares the biochemical structure of hemoglobin to myoglobin.

B1. Diagram of the Amino Acid Difference The candidate does not provide an original diagram that demonstrates the amino acid difference between normal and sickle forms of hemoglobin. The candidate provides an inaccurate or incomplete original diagram that demonstrates the amino acid difference between normal and sickle forms of hemoglobin. The candidate provides an accurate and complete original diagram that demonstrates the amino acid difference between normal and sickle forms of hemoglobin.

B2. Diagram of Normal and Sickle Red Blood Cells The candidate does not provide an original diagram that demonstrates the difference between normal and sickle red blood cells at the cellular level. The candidate provides an inaccurate or incomplete original diagram that demonstrates the difference between normal and sickle red blood cells at the cellular level. The candidate provides an accurate and complete original diagram that demonstrates the difference between normal and sickle red blood cells at the cellular level.

B3. Diseased Cells vs. Normal Red Blood Cells The candidate does not provide a logical explanation of how diseased cells differ from normal red blood cells in their capacity to transport oxygen. The candidate provides a logical explanation, with insufficient detail, of how diseased cells differ from normal red blood cells in their capacity to transport oxygen. The candidate provides a logical explanation, with sufficient detail, of how diseased cells differ from normal red blood cells in their capacity to transport oxygen.

B4a. Inheritance in Sickle Cell Anemia The candidate does not accurately identify the type of inheritance seen in sickle cell anemia. Not applicable. The candidate accurately identifies the type of inheritance seen in sickle cell anemia.

B4b. Diagram of Sickle Cell Gene Inheritance The candidate does not provide an original diagram, or series of simple diagrams, that demonstrates how sickle cell genes are inherited. The candidate provides an inaccurate or incomplete original diagram, or series of simple diagrams, that demonstrates how sickle cell genes are inherited. The candidate provides an accurate and complete original diagram, or series of simple diagrams, that demonstrates how sickle cell genes are inherited.

C. Sources When the candidate uses sources, the candidate does not provide in-text citations and references for each source used. When the candidate uses sources, the candidate provides appropriate in-text citations and references with major deviations from APA style. When the candidate uses sources, the candidate provides appropriate in-text citations and references accurately or with only minor deviations from APA style, OR the candidate does not use sources.

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